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Ransformation enzymes such as CYPs are often considered as double-edged swords because they may not only detoxify harmful chemicals but also create moretoxic electrophilic metabolites that can damage cellular macromolecules such as DNA [12]. Generation of reactive oxygen species (ROS) intermediate metabolites leads to activation of Nrf2 which induces antioxidant enzyme genes including glutathione-
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Ologs. The second objective of the study was to examine the genome wide transcriptional responses to xenobiotic compounds using whole genome tiling arrays recently made available in Oikopleura. Oikopleura was exposed to two model xenobiotic compounds benzo[a]pyrene (BaP) and clofibrate (Clo) that are common environmental pollutants. BaP is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that
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Ologs. The second objective of the study was to examine the genome wide transcriptional responses to xenobiotic compounds using whole genome tiling arrays recently made available in Oikopleura. Oikopleura was exposed to two model xenobiotic compounds benzo[a]pyrene (BaP) and clofibrate (Clo) that are common environmental pollutants. BaP is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that
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There are many ways to help someone recover from trauma. For the simplest of cases, just the simple reminder that you are not alone can help a lot in alleviating the suffering brought by traumatic experiences. If you know someone who is in this situation, just do your best to be by his or her side from time to time and the trauma will slowly go away. But for cases that are extreme, professional me
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There are many ways to help someone recover from trauma. For the simplest of cases, just the simple reminder that you are not alone can help a lot in alleviating the suffering brought by traumatic experiences. If you know someone who is in this situation, just do your best to be by his or her side from time to time and the trauma will slowly go away. But for cases that are extreme, professional me
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Om neutrophils, eosinophiles, and basophiles. C3a and C5a act on specific receptors to produce local inflammatory responses and when secreted in concentrations high enough to invoke a general systemic response, they cause circulatory collapse similar to an IgE mediated allergic response. ATs modulate the secretion of IL-6, and TNF from B cells and serve as potent chemoattractants[52]. C5a also wor
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Ns A and D are potent endogenous inhibitors of lipid peroxidation and oxidative cellular injury. J Biol Chem 2000, 275:38848-38855. 7. Crowther JE, Kutala VK, Kuppusamy P, Ferguson JS, Beharka AA, Zweier JL, et al.: Pulmonary surfactant protein a inhibits macrophage reactive25.26.27.28.29.oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity. J Immunol 2004, 172:
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Reactive antibodies activate complement still further. The increase in alternative complement proteins, complement receptors and C protein all facilitate a positive feedback loop that can have dangerous consequences in a dengue infected patient.ConclusionThree immune components interact to produce a confluence of symptoms that define DHF/DSS. Dengue virus initially infects immature dendritic cells