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Imilar topology (Additional file 1, Figure S1). See Additional file 2 for the full list of O. dioica CYP proteins and their accessions. O. dioica (Od) sequences are shown in blue.Yadetie et al. BMC Genomics 2012, 13:55 http://www.biomedcentral.com/1471-2164/13/Page 4 ofCYP3-like-2 (CBY21750) and CYP2-like-11 (CBY24358) genes, respectively (Additional files 3 and 4).Lack of detection of AhR signali
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Ologs. The second objective of the study was to examine the genome wide transcriptional responses to xenobiotic compounds using whole genome tiling arrays recently made available in Oikopleura. Oikopleura was exposed to two model xenobiotic compounds benzo[a]pyrene (BaP) and clofibrate (Clo) that are common environmental pollutants. BaP is a carcinogenic polycyclic aromatic hydrocarbon (PAH) that
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Th Gag(p17)-E2 particles induced antigen-specific cytotoxic [65] CD8+ T cellsTh Gag(p17)-E2 particles induced antigen-specific cytotoxic [65] CD8+ T cells able to produce IFN- . Moreover, a moderate neutralizing antibody response was found in rabbits immunized with an E2 scaffold displaying a peptide [67] mimotope of the HIV-1 gp120 bridging sheet . Furthermore, E2 multimeric scaffolds displ
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Tion virosomes and virosomal adjuvanted formulations are currently applied in commercialTion virosomes and virosomal adjuvanted formulations are currently applied in commercial vaccines (Hepatitis A vaccines: Epaxal and Epaxal junior; Influenza vaccines: Inflexal V and FluAd). Moreover several promising virosome vaccine candidates , (Malaria, HCV breast cancer HIV Candida vaccines) are , , ,
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Rger portion of the molecule for modeling, it was later suggested that a cationic loop region promoted nucleation by attracting Ca2+ ions, with the loop's flexibility allowing for rapid self-assembly with phosphate ions [130], rather than providing a regular template for crystallization. The flexible nature of the osteopontin structure when bound to the HA surface, was also predicted by molecular
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Imensional gel analysis: two-dimensional difference gel electrophoresis incorporating a pooled internal standard. Proteomics 2003, 3:36-44. Freeman WM, Brebner K, Amara SG, Reed MS, Pohl J, Phillips AG: Distinct proteomic profiles of amphetamine self-administration transitional states. Pharmacogenomics Journal 2005, 5:203-214. Freeman WM, Hemby SE: Proteomics for protein expression profiling in ne
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Vely been investigated as vaccine and drug delivery systems, adjuvants, nucleicVely been investigated as vaccine and drug delivery systems, adjuvants, nucleic acid delivery [31-34] platforms, and nanocarriers for imaging approaches . Nanoparticle systems can be designed to optimally present antigens in their native conformations to the immune system in controlled, slow release formulations p
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R-activated receptor alpha (PPARa) regulates CYP4A [11-14]. SXR and CAR are closely related nuclear receptors (NR1I) that are activated by a wide range of compounds including several clinically used drugs [15]. AhR is a major xenobioticsensing receptor that is activated by environmental pollutants such as dioxin and PAHs including benzo[a]pyrene (BaP) [16,17]. AhR and its dimerization partner AhR